加入收藏
百奥莱博公司客服电话百奥莱博QQ百奥莱博QQ百奥莱博QQ
百奥莱博公司微信服务号

产品目录

VEGFR3/FLT4抗体图片
产品货号:
Z39060
中文名称:
VEGFR3/FLT4抗体
英文名称:
Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1)
产品规格:
80μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1)
指标别名FLT 4;FLT4;FLT41;Fms like tyrosine kinase 4;fms related tyrosine kinase 4;LMPH1A;PCL;VEGFR 3;VEGFR3
克隆性Monoclonal
检验物种human
应用范围IHC,FCM,WB
基因名称FLT4
克隆号818CT12.1.1
抗体来源Mouse
抗体类型IgG2a
免疫原Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
计算分子量153kDa
成分Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
纯化方式This antibody is purified through a protein G column,followed by dialysis against PBS
保存条件Maintain refrigerated at 2~8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles.
背景资料Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD,and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development.Promotes proliferation,survival and migration of endothelial cells,and regulates angiogenic sprouting.Signaling by activated FLT4 leads to enhanced production of VEGFC,and to a lesser degree VEGFA,thereby creating a positive feedback loop that enhances FLT4 signaling.Modulates KDR signaling by forming heterodimers.The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis.Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades;isoform 2 seems to be less efficient in signal transduction,because it has a truncated C-terminus and therefore lacks several phosphorylation sites.Mediates activation of the MAPK1/ERK2,MAPK3/ERK1 signaling pathway,of MAPK8 and the JUN signaling pathway,and of the AKT1 signaling pathway.Phosphorylates SHC1.Mediates phosphorylation of PIK3R1,the regulatory subunit of phosphatidylinositol 3-kinase.Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185',and of AKT1 at 'Ser-473'.
Uniprot IDP35916

相关搜索:VEGFR3/FLT4抗体VEGFR3抗体FLT4单抗Anti-VEGFR3/FLT4 Antibody (Clone#818CT12.1.1)
首页 |  关于我们 |  联系我们 |  在线咨询 |  网站地图
北京百奥莱博科技有限公司 京ICP备14007103号-3